）| 細胞極性関連 発表論文 （研究の背景・経緯については、） |
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| 2001年 | Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi
Y, Ohnishi T, Ohno S*. Atypical protein kinase C is involved in the evolutionarily conserved PAR protein complex and plays a critical role in establishing epithelia-specific junctional structures. J.Cell Biol. 152: 1183-1196, 2001 |
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| Ebnet K, Suzuki A (equal contribution), Horikoshi Y, Hirose T, Brickwedde M-K.M, Ohno S, Vestweber, D*. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J. 20: 3738-3748, 2001 |
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| Yamanaka T, Horikoshi Y, Suzuki A, Sugiyama Y, Kitamura K, Maniwa R, Nagai Y, Yamashita A, Hirose T, Ishikawa
H, Ohno S*. PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-indued formation of th epithelial junctional complex. Genes to Cells 6:721-731, 2001. |
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| Takaki Y, Hirai S-I, Manabe N, Izumi Y, Hirose T, Nakaya M, Suzuki A, Mizuno K, Akimoto K, Tsukita S, Shuin T, Ohno S*. Dynamic changes in protein components of the tight junction during liver regeneration. Cell Tissue Res. 305: 399-409, 2001 |
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| 2002年 | Mishima A, Suzuki A, Enaka M, Hirose T, Mizuno K, Ohnishi T, Mohri H, Ishigatsubo Y, Ohno
S*. Overexpression of PAR-3 suppresses contact-mediated inhibition of cell migration in MDCK cells. Genes to Cells 7: 581-596, 2002. |
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| Hirose T, Izumi Y, Nagashima Y, Nagai-Tamai Y, Kurihara H, Sakai T, Suzuki Y, Yamanaka T, Suzuki A, Mizuno K, Ohno S*. Involvement of ASIP /PAR-3 in promotion of epithelial tight junction formation. J. Cell Sci. 115: 2485-2495, 2002 |
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| Suzuki A, Ishiyama C, Hashiba K, Shimizu M, Ebnet K, Ohno S*. aPKC kinase activity is required for the asymmetric differntiation of the premature junctional complex during epithelail cell polarization. J. Cell Sci. 115: 3565-3573, 2002 |
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| Nagai-Tamai Y, Mizuno K, Hirose T, Suzuki A, Ohno S*. Regulated protien-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells. Genes to Cells 7:1161-1171, 2002 |
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| 2003年 | Suzuki A*, Akimoto K, Ohno S. (Review) Protein kinase C lambda: A PKC Isotype Essential for the Development of Multicellular Organisms. J. Biochem. 133: 9-16, 2003 |
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| Yamanaka T, Horikoshi Y, Sugiyama Y, Ishiyama C, Suzuki A, Hirose T, Iwamatsu A, Shinohara A. Ohno S*. Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity. Curr. Biol. 13: 734-43, 2003 |
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| Mizuno K, Suzuki A, Hirose T, Kitamura K, Kutsuzawa Y, Futaki M, Amano Y, Ohno S*. Self-association of PAR-3 mediated by the conserved N-terminal domain contributes to the development of epithelial tight junction. J. Biol. Chem. 278: 31240−31250, 2003. |
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| 2004年 | Suzuki A*, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose
H, Amano Y, Izumi N, Miwa Y, Ohno S*. aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr. Biol. 14: 1425-1435, 2004 |
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| Ebnet K*, Suzuki A, Ohno S, Vestweber D. (Review) Junctional adhesion molecules (JAMs): more molecules with dual functions? J. Cell Sci. 117: 19-29, 2004 |
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| 2006年 | Yamanaka T, Horikoshi Y, Izumi N, Suzuki A, Mizuno K, Ohno S*. Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity. J. Cell Sci. 119: 2107-2128, 2006 |
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| Iden S, Rehder D, August B, Suzuki A, Wolburg-Buchholz K, Wolburg H, Ohno S, Behrens J, Vestweber D, * Ebnet
K. A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep. 7:1239-1246, 2006 |
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| Suzuki A* and Ohno S.(Review) The PAR-aPKC system: lesson in polarity. J. Cell Sci. 119: 979-987, 2006 |
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| 2007年 | Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, Lu H, Ohnishi N, Azuma T, Suzuki A, Ohno S, Hatakeyama M*. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity Nature 447: 330-333, 2007 |
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| 2008年 | Kishikawa M, Suzuki A*, Ohno S. aPKC enables development of zonula adherens by antagonizing centripetal contrction of the circumferential actomyosin cables. J. Cell Sci. 121: 2481-2492, 2008 |
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| Ebnet K*, Iden S, Gerke V, Suzuki A. (Review) Regulation of epithelial and endothelial junction by PAR proteins. Frontiers in Bioscience. 13: 6520-6536, 2008 |
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| 2009年 | Masuda-Hirata M, * Suzuki A, Amano Y, Yamashita K, Ide M, Yamanaka T, Sakai M, Imamura M, * Ohno S. Intracellular polarity protein PAR-1 regulates extracellular laminin assembly by regulating the dystroglycan complex. Genes to Cells 14:835-50, 2009 |
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| Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S*. Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells. J. Cell Sci. 122:1595-1606, 2009 |
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| Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A, * Hirotsune S. An essential role of the aPKC-Aurora A-NDEL1 pathway on neurite elongation by modulation of microtubule dynamics. Nat Cell Biol. 11: 1057-1068, 2009 |
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| 2010年 | Yamashita K, Suzuki A*, Satoh Y. Ide M, Amano Y, Masuda-Hirata M, Hayashi Y, Hamada K, Ogata
K, Ohno S*. The 8th and 9th tandem spectrin-like repeat of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase Par-1b. Biochem. Biophys. Res. Commun. 391: 812-817, 2010 |
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| 2011年 | Hayashi K, Suzuki A*, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S. Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth. J Neurosci. 31: 12094-12103, .2011. | |
| Hayashi K, Suzuki A*, Ohno S . A novel function of the cell polarity-regulating kinase PAR-1/MARK in dendritic spines. Bioarchitecture 1: 261-266, 2011. Revie |
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| 2012年 | Hayashi K, Suzuki A*, Ohno S. PAR-1/MARK: a kinase essential for maintaining the dynamic state of microtubules. Cell Struct Funct. 37 :21-25, 2012 Review |
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| Iden S, Misselwitz S, Peddibhotla SS, Tuncay H, Rehder D, Gerke V, Robenek
H, Suzuki A, Ebnet K*. aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol. 196: 623-39, 2012 |
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| 日本語総説 | ||
| 2012年 | 鈴木 厚 ｢普遍的細胞極性制御システム：PAR-aPKCシステムの作用機構｣ 生体の科学 特集 細胞極性の制御 , 63(3) 189-195, 医学書院，2012 | |
| 2005年 | 鈴木 厚、大野茂男, 「aPKC/PARシステム：多細胞生物の細胞極性を普遍的にコントロールする分子制御装置」 細胞工学 24(3) 227-230, 秀潤社, 2005 |
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| 2003年 | 鈴木 厚 「細胞極性制御の分子機構」 細胞 35(13) 増大号 44−47，ニューサイエンス社，2003 | |
| 2002年 | 鈴木 厚 ｢プロテインキナーゼCの生理的機能の解明にむけた研究戦略｣ 実験医学 プロテオミクス時代のタンパク質研究 20(14) 増刊号 161-167, 羊土社，2002 | |
| 2000年 | 鈴木 厚 ｢哺乳動物上皮細胞の極性形成におけるaPKCの役割｣ 細胞工学19(12) 1763-1768, 秀潤社, 2000 | |
| 鈴木 厚、大野茂男, ｢哺乳動物上皮細胞の極性形成とプロテインキナーゼ:aPKC｣ 生体の科学 特集 細胞極性の形成機序 51(2) 96-102, 医学書院，2000 | ||